Continuous intracoronary nitroglycerin infusion for spasm after angioplasty

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Intracoronary continuous adenosine infusion.

BACKGROUND Various methods are used to induce maximal hyperemia for physiologic studies, but the feasibility and efficacy of continuous intracoronary (IC) infusion of adenosine for measurement of fractional flow reserve (FFR) has not been well-defined. METHODS AND RESULTS Patients with intermediate coronary artery stenosis were consecutively enrolled. In the phase I study, FFR was measured af...

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Action of intracoronary nitroglycerin in refractory coronary artery spasm.

Coronary artery spasm usually responds to sublingual nitroglycerin. This report describes four patients with variant angina and one patient with rest angina who had coronary spasm that was refractory to sublingual or i.v. nitroglycerin. In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine. In each case, 25-100 micrograms of intracoronary nitroglycerin prom...

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Failure of Intracoronary Nitroglycerin

Relief of angina by nitroglycerine has been attributed to two possible mechanisms: (1) Increase in myocardial blood supply by direct acton of the drug on the coronary arteries. (2) Reduction in myocardial oxygen demand by action of the drug on the systemic circulation. Sublingual application of nitroglycerin in previous studies did not allow the ruling out of the operation of either or both mec...

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ژورنال

عنوان ژورنال: Clinical Cardiology

سال: 1983

ISSN: 0160-9289,1932-8737

DOI: 10.1002/clc.4960061206